Effect of siRNAs on HSV-1 Plaque Formation and Relative Expression Levels of RR mRNA / 中国病毒学·英文版
Virologica Sinica
;
(6): 40-46, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-382731
ABSTRACT
RNA interference(RNAi)is a process by which introduced small interfering RNA(siRNA)can cause the specific degradation of mRNA with identical sequences. The human herpes simplex virus type 1(HSV-1)RR is composed of two distinct homodimeric subunits encoded by UL39 and UL40, respectively. In this study, we applied siRNAs targeting the UL39 and UL40 genes of HSV-1. We showed that synthetic siRNA silenced effectively and specifically UL39 and UL40 mRNA expression and inhibited HSV-1 replication. Our work offers new possibilities for RNAi as a genetic tool for inhibition of HSV-1 replication.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Virologica Sinica
Año:
2011
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS