Progress of virulence determinants in community-associated methicillin-resistant staphylococcus aureus / 国际儿科学杂志

ABSTRACT

Methicillin-resistant staphylococcus aureus (MRSA) remains a prominent human pathogen.Traditionally, MRSA infections occurred exclusively in hospitals and were limited to immunocompromised patients or individuals with predisposing risk factors. However, recently there has been a worldwide epidemic caused by community-associated (CA)-MRSA strains, which can cause severe infections that can result in necrotizing fasciitis or even death in otherwise healthy children or adults outside of healthcare settings. People have made great progress to explain the reasons for enhanced virulence of CA-MRSA, here we review the recent progress made towards four virulence determinants, which are Panton-Valentine leukocidin (PVL), α-Hemolysin (Hla),α-type phenol-soluble modulin ( PSMα) and arginine catabolic mobile element (ACM E) .