Effects of pigment epithelium-derived factor on the expression of vascular endothelial growth factor and reactive oxygen species in the human mesangial cells / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 1067-1069, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-385277
ABSTRACT
To investigate the expression of vascular endothelial growth factor (VEGF)and the levels of reactive oxygen species (ROS)in human mesangial cells cultured in high glucose and being intervened by pigment epithelium-derived factor (PEDF). The results showed that with increased glucose concentration, the expressions of VEGF and ROS generation also gradually increased and PEDF significantly downregulated VEGF expression and ROS generation in a dose-dependent manner. PEDF may delay the diabetic nephropathy progress by improving vascular permeability and inhibiting oxidative stress.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Endocrinology and Metabolism
Año:
2010
Tipo del documento:
Artículo
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