Study of the isolation, chemical structure elucidation and biological activities of saponins from roots of Momordica cochinchinesis Spreng

ABSTRACT

Study on the isolation, structure elucidation 2 saponins and antibacterial, antifungal activities and cytotoxicity of saponins from roots of Momordica cochinchinesis Spreng, 4-5 years of age and collected at Tay Ninh in June 2002. Results: 2 saponins of oleanolic acid group were isolated and elucidated from BuOH extract of the root of Momordica cochinchinensis Spreng extraction were momordin Ib and momordin. Saponin's structure was determined by spectrum method and was compared with published data. The results showed that both of saponins have strong antibacterial to E.coli, B.subtillis, and S.aureus without cytotoxicity in the three experimental cell lines