Study on the correlation between oxidative stress and diabetic complications / 中国基层医药

ABSTRACT

Objective To explore the correlation between oxidative stress and the occurrence and progression of diabetic complications in the patients with diabetes. Methods The content of 24 h urinary 8-hydroxy-deoxyguanosine (8-OhdG) in diabetes mellitus (DM) group, diabetic nephropathy (DN) group, diabetic retinopathy (DR)group, diabetic foot(DF) group, diabetic neuropathy (DNP) group and control group were detected, and analyzed. Results The content of 24 h 8-OhdG in DM group, DN group, DR group, DF group, DNP group were significantly higher than that in the control group (P ＜ 0.01), and that in DN group, DR group, DF group, DNP group were significantly higher than that in DM group(P ＜ 0. 01), but the content of 24 h 8-OhdG among DN group, DR group, DF group and DNP group was not statistically signiticant(P ＞0. 05). Conclusion The correlation between the occurrence of diabetic and its complications oxidative stress and the Ievel of oxidative stress in the body was positive related.