Therapeutic observation on the treatment of proteinuria in nephrotic syndrome with Wenshen Xiaobai decoction / 国际中医中药杂志

ABSTRACT

Objective To observe the effects of Wenshen Xiaoban decoction treating proteinuria in nephrotic syndrome and its adverse reactions. Methods A total of 98 patients with proteinuria who were diagnosed of Yang deficiency of both spleen and kidney by TCM were randomly recruited into a control group (38 patients) and a treatment group (60patients). The treatment group was treated with Wenshen Xiaobai decoction, while the control group was treated with Shenyan Siwei tablets. 24h urine protein, serum albumin (Alb), blood urea nitrogen (BUN), serum creatinine (Scr), and the changes in clinical symptoms were observed before and after the treatment in both groups. Results The treatment group showed better results in 24 hours' urine protein, BUN, Scr, Alb and clinical symptoms than the control group, the difference showing statistical significance(P＜0.05). Conclusion Wenshen Xiaobai decoction can decrease proteinuria and improve renal function and clinical symptoms in NS patients belonging to Yang deficiency of both spleen and kidney.