Expression and significance of endothelin-1 in mucosa of urothelial transitional cell carcinoma / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 557-558, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-387466
ABSTRACT
Objective To investigate the expression and significance of endothelin-1 ET-1 in urothelial transitional cell carcinoma. Methods Immunohistochemistry was applied to detect ET-1 expression in 30 cases of urothelial transitional cell carcinoma and 20 cases of normal urothelial transitional cell samples, the results were analyzed in combination with clinical data. Results ET-1 expression in urothelial transitional cell carcinoma was 40.5%, which was significantly higher than that in normal urothelial transitional cell samples(P <0.05). ET-1 expression was correlated with grade and stage of urothelial transitional cell carcinoma (P <0.05). Conclusion The over expression of ET-1 in urothelial transitional cell carcinoma tissues correlates closely with cancer genesis progression and invasiveness, suggesting that ET-1 might be a biomarker and as a therapeutic target in human urothelial transitional cell carcinoma.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of International Oncology
Año:
2010
Tipo del documento:
Artículo
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