Brief synthetic method of (N-bis(2-acyloxyethyl)-amino)-acetic acid. Application in synthesis of camptothecin-clorambucil complex utilized in the treatment of cancer
Pharmaceutical Journal
;
: 7-10, 2005.
Artículo
en Vietnamita
| WPRIM
| ID: wpr-3881
ABSTRACT
Study on synthesis of [bis(2-acyloxyethyl)-amino]-acetic acid derivatives vat by synthetic method at solid phase and applying this method to synthesize a compound between camptothecin and clorambucil. Result:
camptothecin - clorambucil CPT-2CLR compound were synthesized successfully by camptothecin esterification reaction with 2 (acid[bis(2-acyloxyethyl)-amino]-acetic). The [bis(2-acyloxyethyl)-amino]-acetic acid was synthesized simply and conveniently only by three-step on solid phase from bromoacetic trityl resin, diethanolamin and clorambucil. Attained productivity started from resin was 88%. This method may be applied in the synthesis of similar prodrugs and/or twin drugs
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
Ácido Acético
/
Neoplasias
Idioma:
Vietnamita
Revista:
Pharmaceutical Journal
Año:
2005
Tipo del documento:
Artículo
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