The Role of NF-kappaB in Colon Cancer / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 3-7, 2011.
Artículo
en Coreano
| WPRIM
| ID: wpr-38824
ABSTRACT
Colon cancer is the 3rd common malignancy and 4th common cause of cancer death in Korea. Recent studies have shown that abnormal inflammatory response plays a critical role in colon carcinogenesis. A striking example of connection between inflammation and cancer is NF-kappaB, in which key regulator of inflammation and immune response is associated with target for colon cancer treatment. Constitutive NF-kappaB expression in colon cancer is 40-80% in vivo as well as in vitro, and the inactivation of IKKbeta subunit can reduce tumor multiplicity. The possible mechanisms by which NF-kappaB can contribute to colon carcinogenesis include the activator of antiapoptotic gene expression, enhanced cell survival and proliferation, regulation of angiogenesis and promotion of metastasis of cancer cells. Recent insights into the role of NF-kappaB involved in colon cancer development as well as their relevance as therapeutic targets are herein discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
FN-kappa B
/
Neoplasias del Colon
/
Quinasa I-kappa B
/
Inflamación
Límite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Año:
2011
Tipo del documento:
Artículo
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