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Helicobacter pylori Infection is Associated with Elevated Low Density Lipoprotein Cholesterol Levels in Elderly Koreans
Journal of Korean Medical Science ; : 654-658, 2011.
Artículo en Inglés | WPRIM | ID: wpr-38916
ABSTRACT
This study was conducted to investigate the association between Helicobacter pylori (H. pylori) infection and the lipid profile among elderly Koreans. A total of 462 subjects (mean age 66.2 +/- 7.6 yr, 84% males) who underwent health check-up were investigated. Each subject underwent gastroduodenoscopy with gastric mucosal biopsy, and H. pylori infection was determined by histopathological examination using the updated Sydney System score. The presence of H. pylori infection was significantly associated with the elevated serum levels of total cholesterol and low density lipoprotein (LDL) cholesterol (P 0.05 for each). After controlling confounders, multiple logistic regression analysis showed that the odds ratio of H. pylori infection for high LDL cholesterol level (> 140 mg/dL) was 3.113 (95% confidence interval, 1.364-7.018; P = 0.007). There were no significant associations between the presence of H. pylori infection and elevated total cholesterol levels (> 200 mg/dL) in this model (P = 0.586). The results of this study demonstrate that H. pylori infection is associated with the elevated serum LDL cholesterol levels in elderly Koreans, supporting the hypothesis that H. pylori plays a role in promoting atherosclerosis by modifying lipid metabolism.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Úlcera Péptica / Helicobacter pylori / Infecciones por Helicobacter / Endoscopía / Aterosclerosis / República de Corea / Mucosa Gástrica / Gastritis / Inflamación / LDL-Colesterol Límite: Anciano / Aged80 / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Úlcera Péptica / Helicobacter pylori / Infecciones por Helicobacter / Endoscopía / Aterosclerosis / República de Corea / Mucosa Gástrica / Gastritis / Inflamación / LDL-Colesterol Límite: Anciano / Aged80 / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2011 Tipo del documento: Artículo