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Scoring of prognostic factors that influence long-term survival in patients with hepatic metastasis of colorectal cancer
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 146-151, 2011.
Artículo en Inglés | WPRIM | ID: wpr-38996
ABSTRACT
BACKGROUNDS/

AIMS:

To find independent predictors that affect the survival in patients with hepatic metastasis of colorectal cancer after surgery and to devise a risk scoring system.

METHODS:

Among 150 patients who underwent hepatic resection after diagnosis of colorectal cancer with hepatic metastasis between March 1994 and February 2009, we analyzed clinical, pathologic and outcome data retrospectively.

RESULTS:

The 1-year survival rate was 83%, and the 5-year survival rate was 35%. Nine factors were found to be independent predictors of adverse outcome by univariate

analysis:

stage of primary tumor, CA19-9 >36 U/ml, extrahepatic disease, distribution of the hepatic tumor, number of hepatic tumors >3, largest hepatic tumor >5 cm, total size >10 cm, CEA >10 ng/ml, and metachronous cancer. The last two of these criteria were also significant risk factors on multivariate analysis. When these criteria were used as a risk scoring system, assigning one point for each criterion and dividing the cases into A, B and C groups, the total score was highly predictive of outcomes (p<0.001). No patients in group C (6 to 9 points) were long-term survivors.

CONCLUSIONS:

Long-term outcome can be predicted from nine criteria that are readily available for all patients. Patients meeting up to two criteria (group A) are more likely to have a favorable outcome compared to the three or over (groups B and C). This scoring system may offer an easy, rapid, and reliable prognostic indicator of survival outcome after hepatic resection in patients with hepatic metastasis from colorectal cancer.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Colorrectales / Análisis Multivariante / Tasa de Supervivencia / Factores de Riesgo / Metástasis de la Neoplasia Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Korean Journal of Hepato-Biliary-Pancreatic Surgery Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Colorrectales / Análisis Multivariante / Tasa de Supervivencia / Factores de Riesgo / Metástasis de la Neoplasia Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Korean Journal of Hepato-Biliary-Pancreatic Surgery Año: 2011 Tipo del documento: Artículo