Regional myocardial function and genetic bases in patients with hypertrophic cardiomyopathy / 国际儿科学杂志

ABSTRACT

Hypertrophic cardiomypathy is a genetically heterogeneous cardiac disease transmitted as an autosomal dominant trait,mostly caused by mutant of myofribrilla gene such as β-MHC, MYBPC3, cTnT.cTnI,cTnC, a-Tm and some other gene which coding non-myofribrilla. Different mutant caused different regional myocardium systolic or diastole function, which involve in dysfunction of systolic and diastolic deformation, increase of the sensitive of Ca2+ . This review summarizes the most common gene mutations in hypertrophic cardiomypathy and explains the changes of myocardial functions.