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Migraine-like Headache in a Patient with Complement 1 Inhibitor Deficient Hereditary Angioedema
Journal of Korean Medical Science ; : 104-106, 2012.
Artículo en Inglés | WPRIM | ID: wpr-39057
ABSTRACT
We report on an angioedema patient with a genetic defect in complement 1 inhibitor, manifesting migraine-like episodes of headache, effective prophylaxis with Danazol, and triptan for a treatment of acute clinical episode. The patient was 44-yr-old Korean man with abdominal pain and headache, who was brought into the Emergency Department of Seoul National University Hospital, Seoul. He suffered from frequent attacks of migraine-like headache (3-7 per month), pulsating in nature associated with nausea. Severities were aggravated by activity and his headache had shown recent progression with abdominal pain. No remarkable findings were observed on radiologic examination, brain magnetic resonance images and intracranial and extracranial magnetic resonance angiography. Danazol 200 mg every other day was subsequently used. Following administration of Danazol, symptoms showed improvement and the patient was discharged. While taking Danazol, the migraine-like episodes appeared to be prevented for about 2 yr. At the eighth month, he suffered a moderate degree of migraine-like headache; however, administration of naratriptan 2.5 mg resolved his problem. A case of genetic defect of C1-INH deficiency presented with headache episodes, and was controlled by Danazol and triptan. It suggests that pathogenic mechanism of headache in hereditary angioedema may be mediated by the neurogenic inflammatory-like physiology of migraine.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Piperidinas / Vasoconstrictores / Encéfalo / Triptaminas / Angiografía por Resonancia Magnética / Danazol / Antagonistas de Estrógenos / Proteína Inhibidora del Complemento C1 / Angioedemas Hereditarios / Trastornos Migrañosos Límite: Adulto / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Piperidinas / Vasoconstrictores / Encéfalo / Triptaminas / Angiografía por Resonancia Magnética / Danazol / Antagonistas de Estrógenos / Proteína Inhibidora del Complemento C1 / Angioedemas Hereditarios / Trastornos Migrañosos Límite: Adulto / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2012 Tipo del documento: Artículo