Cell competition and cancer / 国际肿瘤学杂志

ABSTRACT

Cell competition is a phenomenon that the expansion of superior cells at the expense of surrounding inferior cells.It makes sense as a mechanism to maximize tissue fitness and optimize organ function.However,disadjust cell competition may also result in proliferation of abnormal cells.If such a cellular activity in model organisms(such as D.melanogaster)does exist in human,it might help to understand the early events of carcinogenesis and explain some pathological findings.It could be useful for early diagnosis and therapy of cancer.