A-kinase anchoring protein 12 and tumors / 国际肿瘤学杂志

ABSTRACT

A-kinase anchoring protein 12 (AKAP12) ,is a kind of cell scaffold proteins,and can organize the complex of protein kinase A(PKA) and PKC as well as other signal molecules such as cyclin D1,and it is an important regulator of the β2-adrenergic receptor complex,which demonstrates the participation of AKAP12 in diverse signal transduction pathways.AKAP12 contains deletions or downregulation in variours tumors,including prostate cancers,gastric carcinomas and esophagus cancer,suggesting that the inactivation of AKAP12 expression may be linked to oncogenesis.AKAP12 is also a potential suppressor gene in metastasis of cancers.