RNA interference driven by tumor-specific promoters and targeted therapy of tumor / 国际肿瘤学杂志

ABSTRACT

RNA interference driven by tumor specific promoters has targeted therapeutic effect only in tumor tissue,it is a new method in tumor gene therapy,such as alpha-fetoprotein promoter,human telomerase reverse transcriptase promoter,survivin promoter and etc. This method binds specificity of tumor promoter and high effects of RNAi,and can realize specific and highly killing effects in tumor tissue. RNAi driven by tumor specific promoters plays an important role in tumor oncogene targeted therapy.