Research progression of microenviroment hypoxia influencing DNA damage-repair in tumour cells / 国际肿瘤学杂志

ABSTRACT

Microenviroment hypoxia is one of the common phenomenon in cancer,studies have indiacat-ed that hypoxia induces genetic instability via activating many DNA danlage-repair signal pathways,which asso-ciates with tumor invasion and resistance and chemi-radiotherapy resistivity.Here,we overview three main DNA damage-repair pathwaysmismatch repair,homologous recombination and non-homologous end joining,and how hypoxia influences their mechanisms.