Role of COX-2-independent targets of celecoxib and related compounds on cancer prevention and treatment / 国际外科学杂志
International Journal of Surgery
;
(12): 541-544, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-393794
ABSTRACT
We reviewed the role of COX-2 independent targets of celecoxib and related compounds in cancer prevention and treatment. Direct non-COX-2 targets of celecoxib might be protein-dependent kinase 1 (PDK-1),Ca+ ATPase and carbonic anhydrase (CA), and so on; all of which are inhibited by celecoxib and are the main components in various pathways. Inhibition of these proteins leads to the induction of apoptnsis, the inhibition of cell cycle progression, angiogenesis, and metastasis, which are the main mechanisms by which celecoxib exerts its anticarcinogenic activity.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Journal of Surgery
Año:
2009
Tipo del documento:
Artículo
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