The role of 131Ⅰ in the apoptosis of thyrocytes of patient with Graves' disease / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 280-281, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-394166
ABSTRACT
The changes of Fas.FasL and Bcl-2 expression in thyrocytes of patients with Graves'disease were investigated before and 2 weeks after 131Ⅰ administration. The results showed that 131Ⅰ couhl induce thyrocytes to express the apoptotic protein Fas, FasL and the anti-apoptotic protein Bet-2 in patients with Graves'disease. A statistically significant correlation was found between the dose of 131Ⅰ and the expression levels of Fas and FasL but not Bet-2 ,suggesting that early onset of hypothyroid after 131Ⅰ administration may be due to the increased expression of Fas and FasL in thyrocytes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Endocrinology and Metabolism
Año:
2009
Tipo del documento:
Artículo
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