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Mechanism and Interference therapy of HMGB1 after Ischemia/Reperfusion Injury / 国际外科学杂志
International Journal of Surgery ; (12): 424-427, 2009.
Artículo en Chino | WPRIM | ID: wpr-394452
ABSTRACT
After operations such as organ transplantation or cardiopulmonary bypass complicated with is-chemia/reperfusion injury,activated inflammatory cells can express and secret HMGB1,and cooperate with other inflammation factor to induce tissue damage.The mechanism is HMGB1 actives such receptors as TLRs,RAGE,TM,and NF-κB transcription factor,P38MAPK pathway,induce releasing of HMGB1 itself and other inflammation factors.Different with sepsis,HMGB1 emerges much earlier,lasting longer.Inter-ference therapy of HMGB1 could effectively decrease secretion of HMGB1 after ischemia/reperfusion injury.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: International Journal of Surgery Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: International Journal of Surgery Año: 2009 Tipo del documento: Artículo