Experimental study on effects of Rhubarb treatment on the ChE and SOD in rats with acute omethoate poisoning / 中国医师杂志

ABSTRACT

Objective To study the effect of Rhubarb as a supplemental emergency treatment for acute omethoate Poisoning (AOMP). Methods 80 male SD rats were randomly divided into 4 groups slight intoxication group, severe intosieation group, therapeutial group of Rhubarb after severe intoxication and normal control group. The intoxication experimental model (one slight group, two severe groups) were made by intragastrically given at different dose of Omethoate. The severe group was received Rhubarb treatment. Results The rats action in Rhubarb treated group was significantly better than that in control group, and the level of cholinesterase (ChE) and superoxide dismutase (SOD) in serum st different time were significantly higher than those in other two intoxication groups. (P<0. 05 or P <0.01).Conclusions Rhubarb might be good for AOMP as a supple mental emergency therapy.