Relationship between insulin resistance and oxidative stress caused by elevated concentration of free fatty acids / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 205-207, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-395418
ABSTRACT
The relationship between elevated concentration of circulating free fatty acids (FFA) and insulin resistance wag studied,and the pathophysiological mechanism of insulin resistance,especially focused on oxidative stress,was explored.It was found that the elevated circulating FFA level led to insulin resistance in rats, which was partly caused by oxidative stress,and that antioxidative treatment was able to reverse the pathologic change.As a result of enhancing reactive oxygen species production[(886±105 vs 427±42)mmol/L,P<0.05] and disrupting antioxidant[(272±47 vs 561±36)μmol/L,P<0.05],elevated concentration of FFA may induce oxidative stress.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Endocrinology and Metabolism
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS