X-ray induced TCR gene mutation of peripheral blood lymphocytes / 中华放射医学与防护杂志
Chinese Journal of Radiological Medicine and Protection
;
(12): 151-154, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-395473
ABSTRACT
objective To study the TCR gene mutation in peripheral blood lymphocytes induced by X-ray exposure using cultured lymphocytes cloning method.Methods Freshly isolated peripheral lymphocytes from healthy aduh donors were irradiated with X-ray in doses ranging from 0 to 8 Gy and cultured with interleukin2 and phytohemagglutinin for 7 days.The mutant frequencies of TCR gene(TCR MF)were detected by flow cytonletry and the dose response curves were fitted.Results TCR MF increased with the dose going up.An aquadratic polynomial dose response model was fitted.Conclusions TCR gene mutation could which serve as a potential biological dosimeter.It might be applied for the estimation of biological dose in emergency exposure.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Radiological Medicine and Protection
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS