Ulcer healing effect of Helicobacter pylori eradication in patients with Helicobacter pylori-associated peptic ulcer / 대한내과학회지

ABSTRACT

BACKGROUND: Proton pump inhibitor-based triple therapy is effective first line treatment for Helicobacter pylori (H. pylori) infection. However, it is unclear that additional acid-suppression therapy should be continued for ulcer healing after eradication of H. pylori in patients with peptic ulcer diseases. We evaluated the effect of H. pylori eradication in the treatment of H. pylori-associated peptic ulcer diseases. METHODS: Eighty patients with endoscopically proven active peptic ulcers with H. pylori infection were randomized to receive either 1 week therapy of omeprazole 20 mg bid plus clarithromycin 500 mg bid plus amoxicillin 1000 mg bid alone (OCA group) or same regimen followed by 3 weeks of ranitidine 150 mg bid (OCAR group). Endoscopy, clinical assessments and urea breath test were performed after treatment. RESULTS: Overall healing rates of peptic ulcer after 4 weeks and 8 weeks of treatment were 89.7% and 97.4% in OCA group and 85.5% and 97.6% in OCAR group, respectively (p>0.05). The H. pylori eradication rates in OCA and OCAR group were 84.6% and 82.9%, respectively (p>0.05). Symptomatic relief rate after 4 weeks of treatment was 89.2% in OCA group and 92.5% in OCAR group (p>0.05). CONCLUSION: One-week OCA therapy without additional acid suppressing therapy seemed to be effective for the treatment of non-complicated H. pylori-associated peptic ulcer diseases. Further study will be necessary to evaluate the effect of H. pylori eradication in the treatment of peptic ulcer disease and factors affecting healing of the ulcer.