Combination of glucotoxicity and lipitoxicity impairs pancreatic β-cell function / 中华内分泌代谢杂志

ABSTRACT

The effects of elevated levels of glucose and (or) free fatty acids on insulin secretion were studied in obese rats by intravenous glucose tolerance test and isolated pancreas perfusinn. The results showed that both glucose- and arginine-stimulated insulin secretions were severely impaired by glucolipotoxicity and the production of ketone was increased dramatically.