Progress in research of polyamidoamine dendrimers as gene carriers / 国际生物医学工程杂志
International Journal of Biomedical Engineering
;
(6): 308-311, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-398106
ABSTRACT
Polyamidoamine (PAMAM) dendrimers is considered a better genetic carrier for its ability to form with DNA a nano-sized polyelectrolyte complex of high stability and dissolubility. The mechanism of PAMAMmediated gene endocytosis has been fairly clear and the researches in vitro have confirmed that PAMAM had high transfection efficiency and low cytotoxicity. The researches in vivo have further confirmed that PAMAM had a potential application foreground in the field of gene therapy including in the prevention and treatment of ewing's sarcoma and pulmonary fibrosis, in heart transplantation, and in the preparation of falciparum malaria vaccine.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Journal of Biomedical Engineering
Año:
2008
Tipo del documento:
Artículo
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