Relationship between the level of serum C-reactive protein and prognostic value in patients with congestive heart failure / 中国基层医药

ABSTRACT

Objective To determine whether the level of serum C-reactive protein(CLIP) had prognestie val-ue in patients with congestive heart failure(CHF). Methods Serum CRP was measured by enzyme-linked immuno-assay. Results CRP concentration was ( 8.66±4.38 ) mg/L in CHF patients and (1.12±0.87)mg/L in controls( P<0.01). In patients with LVEF ≤35% and > 35%, CRP was ( 11.92±4.55 ) mg/L and ( 5.88±1.92) mg/L( P<0.01 ). In patients with heart function class Ⅰ,Ⅱ,Ⅲ and Ⅳ, CRP was ( 3.92±0.79 ) mg/L, (5.03±1.55 ) mg/L,(8.94±2.97)mg/L, ( 12.21±4.43 ) mg/L, respectively. A negative correlation was observed between serum C RP concentration and LVEF in patients with CHF( r=-0.502,P<0.01 ). According to the concentration of CLIP,83 pa-tients with CRP≥10mg/L had mortality of 32.50% ,109 patients with CRP<10mg/L and ≥5mg/L had mortality of 10.48%,and 150 patients with CRP < 5mg/L had mortality of 2.76%. Conclusion This study shows that serum CRP is increased and has prognostic value in patients with CHF,that the level of CRP is parallel to the severity of CHF.