Primary adrenal non-Hodgkin iymphoma (two cases report and review of the literature) / 中华泌尿外科杂志

ABSTRACT

Objective To discuss the diagnosis and treatment of primary adrenal lymphoma(PAL).Methods Two cases of PAL were retrospectively analyzed and the literature was reviewed.Results One patient received laparoscopic right adrenalectomy and was diagnosed as B cell Non Hodgkin's lymphoma by pathology.Immunohistochemical stains showed positive for CD20 (B cell originmarker) but negative for CD3.0ne cycle CHOP ( eyclophosphamide,doxorubicin,vincristine,andprednisone) chemotherapy was given post operation but the patient died three months after operationbecause of dyscrasia.Another patient received 2-stage bilateral laparoscopic adrenalectomy.Immuno histoehemical staining demonstrated positive CD3 (T cell origin marker) activity,but negative CD20 ac tivity and T cell Non l lodgkin's lymphoma was confirmed.Then the patient received four cyclesCHOP chemotherapy and was in good condition during S months follow up.Conclusions PAL is arare disease and has a poor prognosis.Most reported PAL patients who received only one therapeuticmodality have unsatisfactory survival rates.A combination of therapeutic modalities such as surgeryfollowed by chemotherapy and/or radiotherapy may improve prognosis for patients with PAL than sin gle modality therapy.