Effect of JNK pathway, endoplasmic reticulum stress and oxidative stress on pancreatic islet β cell function / 中华内分泌代谢杂志

ABSTRACT

Though the mechanisms involved in the induction of pancreatic islet β cell dysfunction and apoptosis under diabetes conditions are still not clear, previous studies have shown that triggered or aggravated endoplasmic reticulum stress and oxidative stress play essential roles in impairment of β cell functions, especially the JNK pathway which can be activated by both of them.