Cationic Trypsinogen Gene Mutation in Patients with Chronic Idiopathic Pancreatitis / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 41-46, 2004.
Artículo
en Coreano
| WPRIM
| ID: wpr-40062
ABSTRACT
BACKGROUND/AIMS:
Mutation of Cationic trypsinogen gene is clearly associated with hereditary pancreatitis and plays an important role in the pathogenesis of pancreatitis. According to literature, this mutation is occasionally occurred in patients with pancreatitis in Western countries and Japan. The aim of this study was to find out whether the mutation was observed in Korean patients with chronic idiopathic pancreatitis.METHODS:
Peripheral blood samples of 11 patients with chronic idiopathic pancreatitis were collected consecutively, and DNA was extracted from the samples. Polymerase chain reaction was performed in exon 2 and 3 of cationic trypsinogen gene. Then, DNA products were purified and sequenced.RESULTS:
The mutation was not found in exon 2 and 3 of cationic trypsinogen gene in these patients.CONCLUSIONS:
There was no cationic trypsinogen mutation in Korean patients with chronic idiopathic pancreatitis. Further large sampled cohort study is needed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pancreatitis
/
Tripsinógeno
/
Resumen en Inglés
/
Tripsina
/
Reacción en Cadena de la Polimerasa
/
Enfermedad Crónica
/
Mutación
Tipo de estudio:
Estudio observacional
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Año:
2004
Tipo del documento:
Artículo
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