Mechanism of the hepatic ischemia-reperfusion injury / 国际外科学杂志

ABSTRACT

Ischemia.reperfusion injury of the liver consists of two distinct phases.The early phase occurs within 2 to 4 hours after reperfusion,which may be mainly induced by the increased production of oxygen radical species.The late phase results from inflammatory responses at 6 hours or more after reperfusion,leading to the progression of liver damage.The mechanism of IRIof the liver is a complex and muhifactorial process.The review outlines the current progress in the understanding of hepatic IRI from microcirculation,cellular,andmolecular levels,respectively.