Progress of metabolomics in children with nervous system disease / 国际儿科学杂志

ABSTRACT

Metabolomics, the measurement of metabolite concentrations and fluxes in cell systems, is an emerging science that has enormous potential and good application prospect. Metabolomics technology, especially mass spectrometry, has been used extensively in screening children's heredity metabolic disease, and part of these diseases has become to be curing. In this review, we elaborate on the application of metabolomics in early diagnosis of central nervous system infectious disease, screening of lipide metabolism dysfunction in nervous system and childhood autism, with special focus on the finding of cholesterin storage in nerve cell, variations in the metabolism of glucose, which give its promise for diagnosis and treatment of the lipide metabolism dysfunction in nervous system.