The Effect of Fentanyl Patch in the Treatment of Intractable Postherpetic Neuralgia / 대한피부과학회지
Korean Journal of Dermatology
;
: 422-428, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-40365
ABSTRACT
BACKGROUND:
Postherpetic neuralgia is a persistant pain which occurs after the reactivation of varicella zoster infection. It sometimes disrupts the lives of otherwise healthy individuals. A transdermal patch of analgesics such as fentanyl could be a novel and safe method, with less adverse problems, to relieve the prolonged pain in postherpetic neuralgia.OBJECTIVE:
The aim of this study was to evaluate the analgesic effect and safety of transdermal fentanyl patch in intractable postherpetic neuralgia.METHODS:
We applied a fentanyl patch on the chest for 6 days, changing it once on the fourth day. The severity of pain was evaluated by visual analogue scale (VAS), and was assessed before treatment, the first and third day after commencement of treatment, and 1 day after treatment had finished. Any side effects were also checked at each VAS assessment session.RESULTS:
The average VAS pain score of the pretreatment, first, third, and seventh day were as follows; 82.9+/-8.8, 49.6+/-15.8, 45.0+/-16.5, 45.7+/-15.2. Postherpetic neuralgia was dramatically improved from the first day of treatment, and the improved state was maintained until 1 day after the treatment had finished (p<0.05). Several side effects such as contact dermatitis (9.5%), mild nausea (14.3%), and constipation (9.5%) were observed during the treatment.CONCLUSION:
Fentanyl patch is an effective, simple and relatively safe method in the treatment of intractable postherpetic neuralgia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tórax
/
Varicela
/
Fentanilo
/
Estreñimiento
/
Dermatitis por Contacto
/
Neuralgia Posherpética
/
Parche Transdérmico
/
Herpes Zóster
/
Analgésicos
/
Náusea
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Año:
2007
Tipo del documento:
Artículo
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