Effects of sesamin on lipid metabolism in hyperlipidemia rats / 西安交通大学学报(医学版)

ABSTRACT

Objective To study the effects of sesamin on lipid metabolism disorders in hyperlipidemia rats. Methods The hyperlipidemia SD rat models were established with high-fat diet. These rats had been interfered by sesamin for seven weeks, and then had their levels of serum lipids, antioxidant enzymes and peroxidation products determined. The morphological changes in their livers were observed. Results Sesamin could reduce the hyperlipidemia rats' serum total cholesterol, triglyceride, low-density lipoprotein cholesterol and apolipoprotein B levels, and properly increase high-density lipoprotein cholesterol and apolipoprotein A contents (P<0.05). It also reduced the rats' free radical metabolites in serum MDA contents, raised the activities of superoxide dismutase and glutathione peroxidase, and enhanced the body's capacity of inhibiting hydroxyl free radicals (P<0.05). Sesamin of high, medium and low dosage had different effects in relieving liver steatosis of the hyperlipidemia rats. Conclusion Sesamin can regulate lipid metabolism of hyperlipidemia rats, alleviate oxidative stress of the body, and improve liver steatosis.