Clinical significance of chromosomal abnormality in multiple myeloma / 대한내과학회지
Korean Journal of Medicine
;
: 304-312, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-40511
ABSTRACT
BACKGROUND:
Multiple myeloma is a clonal B-cell malignancy manifested by the accumulation of terminally differentiated plasma cells. The disease is characterized by clinical heterogeneity, with survival ranging from a few months to more than 10 years. The purpose of this study is to evaluate the prognostic value of specific chromosomal abnormality in multiple myeloma.METHODS:
We analyzed the clinical records of 40 patients who were diagnosed as multiple myeloma, between April, 1995 and August, 2004. Cytogenetic analysis was conducted by metaphase karyotype analysis. Patients were grouped into normal cytogenetic group (arm A), complete or partial deletion of chromosome 13 and hypodiploidy group (arm B) and other cytogenetic abnormality group (arm C).RESULTS:
Median follow up duration was 13.1 months (range 1.5-92.1). Overall response rate to chemotherapy was 58.8% and response rate among arm A, B and C were 56.3%, 33.3% and 75%, respectively (p=0.229). The prognostic factors affecting survival were clinical stage, performance status, serum creatinine level, sex and chromosomal abnormality. The median overall survival was significantly different among arm A, B and C (34.9 months, 8.5 months and 19.8 months, respectively, p=0.0125).CONCLUSION:
chromosomal abnormality, especially, complete or partial deletion of chromosome 13 and hypodiploidy at initial diagnosis is significantly associated with survival duration.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Brazo
/
Células Plasmáticas
/
Pronóstico
/
Características de la Población
/
Cromosomas Humanos Par 13
/
Linfocitos B
/
Estudios de Seguimiento
/
Aberraciones Cromosómicas
/
Creatinina
/
Análisis Citogenético
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2005
Tipo del documento:
Artículo
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