The expression and clinical significance of FGFR2, and c-Cbl in gastric carcinoma / 中国癌症杂志
China Oncology
;
(12): 609-614, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-405600
ABSTRACT
Background and purpose:
FGFR2 is a receptor tyrosine kinase and c-Cbl is a new RING finger type of ubiquitin ligase in the ubiquitin-proteasomes path. The purpose of this study was to evaluate the expression and significance of FGFR2 and c-Cbl in gastric carcinoma.Methods:
The expression of FGFR2 and c-Cbl were detected by immunohistochemical method of SP.Results:
The positive expression rates of FGFR2 and c-Cbl were 77.4%,71.0% in gastric carcinoma, respectively, both were higher than those normal tissue (P<0.05);The expression of FGFR2 and c-Cbl were positively correlated with depth of invasion and TNM staging, and there was a positive relationship between the expressions of FGFR2 and c-Cbl. Conclusion. The expressions of FGFR2 and c-Cbi were associated with some clinicopathologic features in gastric carcinoma, indicating that their expression may be the prognostic factors for gastric carcinoma.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
China Oncology
Año:
2009
Tipo del documento:
Artículo
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