The Investigation of Solubility of Asarone and Inclusion of Hydroxypropyl Cyclodextrin / 中药新药与临床药理
Traditional Chinese Drug Research & Clinical Pharmacology
;
(6): 371-372, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-406392
ABSTRACT
Objective To investigate effects of different solvent, different temperature and different concentration of hydroxypropyl cyclodextrin on solubility of asarone. Method Determination of asarone solubility in different solvent, at different temperature and different concentration of cyclodextrin were carried out by HPLC-UV method. Results The solubility of asarone in water, tea oil, ethanol, and methanol were 0. 1 mg·mL-1 13.44 mg·mL-1, 1.87 mg·mL-1 and 1.76 mg·mL-1, respectively. The concentration and temperature of cyclodextrin showed a positive correlation with solubility of asarone. At normal temperature, the solubility of asarone in water increased 10 times by 45 % hydroxypropyl cyclodextrin. Conclusion Asarone has poor solubility in water and it can be improved by high concentration of hydroxypropyl cyelodetrin.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Traditional Chinese Drug Research & Clinical Pharmacology
Año:
2009
Tipo del documento:
Artículo
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