Establishment of Rapid Aging Bee Model / 中药新药与临床药理
Traditional Chinese Drug Research & Clinical Pharmacology
; (6): 388-390, 2009.
Article
en Zh
| WPRIM
| ID: wpr-406499
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the possibility of taking bees as laboratory animals and establishing the new rapid ag-ing animal model. Methods The bee model was established under environment of high temperature, lack of oxygen, and vibration. The appropriate conditions for establishing the model were investigated by observing the changes of appearance and measuring the activities of the total SOD and GSH-PX in the whole homogenate of bees. Meanwhile, the changes of biopsy were observed. Results Bees aging model could been set up at the conditions of appropriate temperature, hypoxia and noise. The model has obvious indications of aging, such as reduced activity of SOD and GSH-PX, and obviously pathological changes of brain organization and intestinal tissue. The aging indications are not the most seriously and are suit-able for the studies on drug improving the aging indications. Conclusion Being in the enviroment of high temperature (35 ℃), hypoxia and noise for4 hours, can result in the better bee aging model.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Traditional Chinese Drug Research & Clinical Pharmacology
Año:
2009
Tipo del documento:
Article