Anti-inflammatory effect of Yijie particles and its mechanism / 中国基层医药

ABSTRACT

ObjectiveTo investigate the anti-inflammatory effect and mechanism of Yijie particles. MethodsTook the energometry of SOD in foot of rats metatarsal inflammatory organization induced by egg white,Maked antibacterial experiment investigation in vitro to observe the anti-inflammatory effect of Yijie particles and observed mice abdominal macrophage phagocytosis function of red blood cells. ResultsCompared to the control group,the SOD of content in the large,medium and small dose group were statistically significant difference(all P＜0.01),the mice abdominal macrophage phagocytosis percentage of red blood cells and devour exponential increased significantly(all P＜0.01).4 kinds of pathogenic bacteria of the lowest antibacterial and minimum bactericidal concentration(MBC),respectively,streptococcus pneumoniae(MIC 0.286g/ml,MBC 0.429g/ml);Clay white fungus(MIC 0.140g/ml,MBC 0.275g/ml);Pseudomonas aeruginosa(MIC 0.0177g/ml),MBC 0.0358g/ml);E.coli(MIC 0.429g/ml,MBC 0.429g/ml). ConclusionYijie particles had remarkable anti-inflammatory and better antibacterial effect.