Your browser doesn't support javascript.
loading
Association between Fibrinogen and Carotid Atherosclerosis According to Smoking Status in a Korean Male Population
Yonsei Medical Journal ; : 921-927, 2015.
Artículo en Inglés | WPRIM | ID: wpr-40873
ABSTRACT

PURPOSE:

Although inconsistent, reports have shown fibrinogen levels to be associated with atherosclerosis. Accordingly, since cigarette smoking is associated with increased levels of fibrinogen and atherosclerosis, it may also affect the association between fibrinogen and atherosclerosis. We investigated the associations between fibrinogen and carotid intima-media thickness (IMT) according to smoking status in a Korean male population. MATERIALS AND

METHODS:

Plasma fibrinogen levels were measured in 277 men aged 40-87 years without a history of myocardial infarction or stroke. High-resolution B-mode ultrasonography was used to examine the common carotid arteries. IMT level was analyzed both as a continuous (IMT-max, maximum value; IMT-tpm, 3-point mean value) and categorical variable (higher IMT; presence of plaque). Serial linear and logistic regression models were employed to examine the association between fibrinogen and IMT according to smoking status.

RESULTS:

Fibrinogen levels were positively associated with IMT-max (standardized beta=0.25, p=0.021) and IMT-tpm (standardized beta=0.21, p=0.038), even after adjusting for age, body mass index, systolic blood pressure, fasting glucose, and total cholesterol to high-density lipoprotein cholesterol ratio in current smokers (n=75). No significant association between fibrinogen and IMT, however, was noted in former smokers (n=80) or nonsmokers (n=122). Adjusted odds ratios (95% confidence interval) for having plaque per one standard deviation higher fibrinogen level were 2.06 (1.09-3.89) for current smokers, 0.68 (0.43-1.10) for former smokers, and 1.06 (0.60-1.87) for nonsmokers.

CONCLUSION:

Our findings suggest that cigarette smoking may modify the association between fibrinogen and carotid atherosclerosis. Further studies are required to confirm this finding in different populations.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Presión Sanguínea / Fibrinógeno / Enfermedades de las Arterias Carótidas / Fumar / Índice de Masa Corporal / Modelos Logísticos / Factores Sexuales / Colesterol / Estudios Transversales / Encuestas y Cuestionarios Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Adulto / Anciano / Aged80 / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Yonsei Medical Journal Año: 2015 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Presión Sanguínea / Fibrinógeno / Enfermedades de las Arterias Carótidas / Fumar / Índice de Masa Corporal / Modelos Logísticos / Factores Sexuales / Colesterol / Estudios Transversales / Encuestas y Cuestionarios Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Adulto / Anciano / Aged80 / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Yonsei Medical Journal Año: 2015 Tipo del documento: Artículo