Non-nucleoside reverse transcriptase inhibitors(Part 18): Synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines / 药学学报
Acta Pharmaceutica Sinica
; (12): 145-149, 2009.
Article
en Zh
| WPRIM
| ID: wpr-410151
Biblioteca responsable:
WPRO
ABSTRACT
Eight new diaryltriazine derivatives containing 4-allylamino and 4-azido substitutes guided by molecular docking have been designed and synthesized based on our previous work.The evaluation of HIV inhibitory activity demonstrated that all compounds were potent against HIV-1 replication.The most active compound 7c exhibited activity against HIV-1 (IC50=0.034 μmol·L-1,SI=6475)and the double mutant strain (IC50=9.39 μmol·L-1)in the micromolar range, which was more potent than nevirapine.
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WPRIM
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Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Article