Effect of Erigeron Breviscapini on Chronic Hypoxic Pulmonary Hypertension and Serum Nitric Oxide and Endothelin-1 in Rats / 华中科技大学学报(医学版)
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
;
(6): 224-226, 2001.
Artículo
en Chino
| WPRIM
| ID: wpr-410781
ABSTRACT
To study the effect of Erigeron breviscapini on chronic hypoxic pulmonary hypertension and mechanism,the hypoxic rats were injected intraperitoneally with Erigeron breviscapini. The mPAP,the content of serum nitric oxide (NO) and endothelin-1 (ET-1) were measured 5,14 and 28 days after intraperitoneal injection of Erigeron breviscapini in hypoxia respectively,and were compared with those in the single hypoxic group. The results showed that the contents of serum mPAP and ET-1 were higher,and serum NO was lower in single hypoxic group than in the normal rats (both P<0.01). The contents of serum mPAP and ET-1 were lower and NO was higher in the Erigeron breviscapini-treated group than in the single hypoxic group (P<0.01). It was suggested that Erigeron breviscapini could reduce the hypoxic pulmonary hypertension by increasing NO and decreasing ET-1 of serum. Erigeron breviscapini could be used to treat hypoxic pulmonary hypertension.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
Año:
2001
Tipo del documento:
Artículo
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