The effect of microelement powder on membrane potential of vascular endothelial and smooth muscle cells of rats / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 235-237, 2001.
Artículo
en Chino
| WPRIM
| ID: wpr-410855
ABSTRACT
AIM:
To study the effect of microelement powder (MP) on membrane potential of vascular endothelial and smooth muscle cells of rats in order to elucidate the mechanism of microcirculation improvement by MP.METHODS:
Cultured pulmonary vascular endothelial cells (EC) and aortic smooth muscle cells (SMC) of rats and detecting the changes of cellular membrane potentials by using potential-sensitive fluorescent probe and laser jet confocal microscope.RESULTS:
MP hyperpolarized SMCs significantly. Glybenclamide (2 μmol/L), a blocker of KATP channel, which had no effect on membrane potential of SMCs, reversed the hyperpolarization of MP completely; MP hyperpolarized ECs slightly, but the effect was unaffected by glybenclamide.CONCLUSION:
MP hyperpolarizes SMCs by activating KATP channels and leads to dilation of microvessels and improvement of microcirculation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Pathophysiology
Año:
2001
Tipo del documento:
Artículo
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