Effect of Inhibiting C-myc Gene on Graft Stenosis / 中国医科大学学报
Journal of China Medical University
;
(12): 81-82, 2001.
Artículo
en Chino
| WPRIM
| ID: wpr-411518
ABSTRACT
Objective:
To investigate the effect of inhibitng C-myc expression by actinomycin D on intimal hy-perplasia in vein graft.Methods:
The vein graft model was established in rats. The different dises of actinomycin D (0.015 mg/kg; 0.15 mg/kg) were given just before and after operation. The vein grafts were harvested at 2 hrs and 1 week after grafting. C-myc mRNA was measured by in situ hybridization method. The intimal thickness was measured using a computerised image analysis system.Results:
The expression of C-myc mRNA and the intimal thickness were both significantly reduced in large dose (0.15 mg/kg) group of actinomycin D, with 6.5%; 18.7 μm compared with control group in 12.5%; 28.5 μm respectively.Conclusion:
Actinomycin D can inhibit expression of C-myc mRNA and intimal hyperplasia in graft. Expression of C-myc plays an important role in inducing proliferation of smooth muscle cell in vein graft.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of China Medical University
Año:
2001
Tipo del documento:
Artículo
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