Effect of Levofloxacin on Pharmacokinetics of Phenytoin Sodium in Rabbits / 中国药房
China Pharmacy
;
(12): 83-84, 2001.
Artículo
en Chino
| WPRIM
| ID: wpr-411530
ABSTRACT
AIM:
To study the effect of levofloxacin(LVFX)on serum concentrations and pharmacokinetics of phenytoin sodium(PHT)in rabbits.METHODS:
Using UV-spectrophotometry,the serum concentrations of PHT were determined in nine rabbits before oral feeding LVFS and after a single dose of PHT given iv 10 days later.The pharmacokinetic parameters were worked out with 3p87 program.RESULTS:
The concentration-time curve of PHT was fit to open two-compartment model.After co-administration of LVFX,the serum concentrations of PHT were decreased to some extent and part of pharmacokinetic parameters obviously changed as well.CONCLUSION:
Co-administration of PHT and LVFX will accelerate the metabolic process of PHT.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2001
Tipo del documento:
Artículo
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