PROTECTIVE EFFECT OF GLUTAMINE ON THE INTESTINAL MUCOSAL ANTIOXIDATION IN ENDOTOXEMIC RATS / 中国普外基础与临床杂志

ABSTRACT

Objective To study the protective effect of glutamine on the intestinal mucosal antioxidation in endotoxemic rats. Methods　Twenty-eight male Wistar rats were randomly divided into three groups, group Aparenteral nutrition supplemented with glutamine, group BTPN without glutamine,and group Cnormal control. Endotoxemia was induced by continous intravenous infusion of lipopolysaccharide(LPS) at a dose of 2 mg/kg per day throughout the 5-day study period. The mucosal protein、DNA、ATP、SOD、MDA、GSH、sIgA were determined. Results The mucosal protein、DNA、ATP、SOD、GSH and sIgA content in endotoxic rats were markedly decreased, MDA was increased as compared with normal control(P＜0.05). The former indices in group A were improved and MDA content was decreased as compared with group B(P＜0.05). Conclusion　Glutamine can improve gut energy metabolism, decrease the extent of mucosal injury of free radicals, and give an protective effect on the mucosal probably by increasing GSH.