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Left Ventricular Hypertrophy to Heart Failure in Gradually Pressure Afterload Heart of Wistar Rat / 中国医科大学学报
Journal of China Medical University ; (12): 9-11, 2001.
Artículo en Chino | WPRIM | ID: wpr-412103
ABSTRACT

Objective:

Our purpose was to establish an ideal chronic pressure-afterload heart failure rat model which has the transition from cardiac hypertrophy to heart failure.

Methods:

Chronic pressure-afterload heart failure rat model was induced by gradually constricting the ascending aorta of young rats. Young rats were randomly divided into 2 groups the constricted and sham-operated groups. Clinical manifestation, tail-cuff blood pressure, organ weight, and hemodynamic data were observed at various time after operation.

Results:

The overall survival rate was 87%. Tail-cuff pressure began to increase in 4 weeks after operation. Left ventricular hypertrophy appeared in 12 weeks and heart failure in 5 months.

Conclusion:

It's a practical and reproducible model of cardiac hypertrophy that progresses to chronic heart failure.
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Journal of China Medical University Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Journal of China Medical University Año: 2001 Tipo del documento: Artículo