Observation of the effect of pramipexole combined with levodopa/benserazide in treatment of advanced Parkinson's disease / 中国基层医药

ABSTRACT

Objective To evaluate the efficacy of pramipexole and levodopa/benserazide in treatment of advanced Parkinson's disease.Methods 50 patients with advanced Parkinson's disease were randomly divided into two groups,25 cases in the control group,others in the treatment group.The patients in the control group were treated with levodopa/benserazide and placebo,while those in the treatment group were given pramipexole and levodopa/benserazide.The treatment lasted 16 weeks.The clinical effects before and after the treatment were observed and compared. Results Compared with the control group,the treatment group experienced significant drops in the score of the Unified Parkinson's Disease Rating Scale(UPDRS)(P＜0.05).The clinical efficacy was significantly improved(84.0%vs36.0%)(χ2=10.08,P＜0.01).Conclusion The clinical effect of pramipexole and levedopa/benserazide in treatment of advanced Parkinson's disease was satisfactory,and it should be widely applied.