Influence of ω-3 PUFA on bacterial pneumonia in mice / 肠外与肠内营养
Parenteral & Enteral Nutrition
;
(6): 41-43, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-415248
ABSTRACT
Objective:
To evaluate the protective effect and possible mechanism of ω-3 PUFA supplementation in the early stage of experimental acute bacterial pneumonia in mice.Methods:
Mice of Pseudomonas aeruginosa (PA)-induced lung injury were randomly divided into three groups fish oil supplementation treatment group (n = 8),soybean oil treatment group (n = 8) and normal sodium treatment group (n = 8).Evaluation criteria were inflammatory response 24 h after the injury assessed with TNF-α、IL-1β,IL-10 levels in bronchoalveolar lavage and lung injury evaluation by H-E staining.Results:
Compared with the other two groups,the levels of IL-1β,IL-10 in fish oil supplementation treatment group were reduced.No difference was found in the TNF-α level and histological scoring among the groups.Conclusion:
The ω-3 PUFA can decrease the elevated mediators of inflammation in bacterial pneumonia,but can't affect the pneumonia progress within 24 hours.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Parenteral & Enteral Nutrition
Año:
2010
Tipo del documento:
Artículo
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