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Placental apoptosis in preeclampsia / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology ; : 787-792, 2001.
Artículo en Coreano | WPRIM | ID: wpr-41532
ABSTRACT

OBJECTIVE:

Our purpose was to investigate the incidence of placental apoptosis in pregnancies complicated by preeclampsia.

METHODS:

Placental samples were obtained from 15 uncomplicated third-trimester pregnancies and from 17 pregnancies complicated by preeclampsia. TUNEL (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling) staining and electron microscopy were performed on all placental samples and identified apoptosis within the cells of the placenta. TUNEL positive stained cells were counted at each photograph(five sections were photoragphed at 1,500 magnifications for each sample). We focused on only the syncytiotrophoblast nuclei of the placenta. The number of apoptotic syncytiotrophoblast nuclei identified was expressed as a percentage of total number of syncytiotrophoblast nuclei counted.

RESULTS:

Quantification of apoptosis (mean+/-SD) was as follows normal third trimester (n=15) 0.57+/- 0.47% of cells and preeclampsia third trimester (n=17) 1.41+/-0.67% of cells. The incidence of apoptosis was significantly increased in placentas from pregnancies with preeclampsia compared with normal placentas (p< 0.01).

CONCLUSION:

These results suggest that placental apoptosis may play a role in the pathophysiologic mechanisms of preeclampsia.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Placenta / Preeclampsia / Tercer Trimestre del Embarazo / Trofoblastos / Microscopía Electrónica / Incidencia / Apoptosis / Etiquetado Corte-Fin in Situ / Desoxiuridina Tipo de estudio: Estudio de incidencia / Estudio pronóstico Límite: Femenino / Humanos / Embarazo Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Placenta / Preeclampsia / Tercer Trimestre del Embarazo / Trofoblastos / Microscopía Electrónica / Incidencia / Apoptosis / Etiquetado Corte-Fin in Situ / Desoxiuridina Tipo de estudio: Estudio de incidencia / Estudio pronóstico Límite: Femenino / Humanos / Embarazo Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2001 Tipo del documento: Artículo